To clarify if coronary flow reserve (CFR) is related to insulin resistance or hyperglycemia in normotensive NIDDM, myocardial blood flow (MBF) at baseline and during dipyridamole loading were measured with 13N-ammonia positron-emission tomography. CFR was significantly reduced in NIDDM patients compared with agematched control subjects. CFR in patients with well-controlled NIDDM was significantly higher than in those with poorly controlled NIDDM, whereas insulin resistance was comparable between the two groups. CFR in NIDDM patients was not related to the degree of insulin resistance. CFR correlated significantly with average fasting glucose concentration and average HbA1c, but not with insulin resistance, age, lipid parameters, or blood pressure. In conclusion, control of blood glucose concentration rather than insulin resistance is most likely related to the reduced CFR in NIDDM.
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Complications|
January 01 1998
Hyperglycemia Rather Than Insulin Resistance Is Related to Reduced Coronary Flow Reserve in NIDDM
Ikuo Yokoyama;
Ikuo Yokoyama
Departments of Internal Medicine, University of Tokyo
Tokyo, Japan
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Tohru Ohtake;
Tohru Ohtake
Radiology, University of Tokyo
Tokyo, Japan
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Katsunori Yonekura;
Katsunori Yonekura
Departments of Internal Medicine, University of Tokyo
Tokyo, Japan
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Shin Woo-Soo;
Shin Woo-Soo
Departments of Internal Medicine, University of Tokyo
Tokyo, Japan
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Junichi Nishikawa;
Junichi Nishikawa
Radiology, University of Tokyo
Tokyo, Japan
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Yasuhito Sasaki;
Yasuhito Sasaki
Radiology, University of Tokyo
Tokyo, Japan
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Masao Omata
Masao Omata
Departments of Internal Medicine, University of Tokyo
Tokyo, Japan
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Address correspondence and reprint requests to Dr. Ikuo Yokoyama, Second Department of Internal Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan 113.
Diabetes 1998;47(1):119–124
Article history
Received:
December 10 1996
Revision Received:
September 17 1997
Accepted:
September 17 1997
PubMed:
9421384
Citation
Ikuo Yokoyama, Tohru Ohtake, Shin-ichi Momomura, Katsunori Yonekura, Shin Woo-Soo, Junichi Nishikawa, Yasuhito Sasaki, Masao Omata; Hyperglycemia Rather Than Insulin Resistance Is Related to Reduced Coronary Flow Reserve in NIDDM. Diabetes 1 January 1998; 47 (1): 119–124. https://doi.org/10.2337/diab.47.1.119
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