Disturbances of coronary circulation have been reported in diabetic patients with microvascular complications but without obstructive coronary atherosclerosis. The aim of the present study was to investigate coronary flow reserve in young adult patients with IDDM but without microalbuminuria and diabetic autonomic neuropathy. Coronary flow reserve was determined in 12 nonsmoking male patients with IDDM (age 30.0 ± 6.6 years) and 12 healthy matched volunteers. Groups were similar with respect to blood pressure and serum lipid concentrations, and no subject had a positive family history of coronary heart disease. The patients with IDDM had normal exercise echocardiography and autonomic nervous function tests. Five patients had minimal background retinopathy, and none had microalbuminuria. Positron emission tomography and [15O]H2O were used to measure myocardial blood flow at rest and after dipyridamole administration. The studies were performed during euglycemic hyperinsulinemia (serum insulin ∼70 mU/1). The baseline myocardial blood flow was similar in patients with IDDM and in control subjects (0.84 ± 0.18 vs. 0.88 ± 0.25 ml · g−1 · min−1, NS). The myocardial blood flow during hyperemia was 29% lower in patients with IDDM (3.17 ± 1.57) compared with the control subjects (4.45 ± 1.37 ml · g−1 · min−1 P < 0.05). Consequently, coronary flow reserve (the ratio of flow during hyperemia and at rest) was lower in diabetic patients than in control subjects (3.76 ± 1.69 vs. 5.31 ± 1.86, P < 0.05) and the total coronary resistance during hyperemia was higher in diabetic patients (53.7 ± 31.5) compared with the control subjects (31.4 ± 11.6 mmHg · min · g · ml−1 P < 0.05). The coronary flow reserve was similar in diabetic patients with and without mild background retinopathy. No association was found between the coronary flow reserve and serum lipid or HbAlc values in either group. Coronary flow reserve is impaired in young adult males with IDDM and no or minimal microvascular complications and without any evidence of coronary heart disease. This abnormality cannot be explained by standard coronary heart disease risk factors. The results imply early impairment of coronary vascular reactivity in IDDM patients, which may represent an early precursor of future coronary heart disease or may contribute to the pathogenesis of diabetic cardiomyopathy.
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Complications|
February 01 1998
Coronary Flow Reserve Is Reduced in Young Men With IDDM
Olli-Pekka Pitkänen;
Olli-Pekka Pitkänen
Department of Medicine
Turku
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Olli T Raitakari;
Olli T Raitakari
Department of Clinical Physiology
Turku
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Tapani Rönnemaa;
Tapani Rönnemaa
Department of Medicine
Turku
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Pertti J Koskinen;
Pertti J Koskinen
Department of Clinical Chemistry
Turku
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Hidehiro Iida;
Hidehiro Iida
Research Center for Brain and Blood Vessels
Akita, Japan
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Terho J Lehtimäki;
Terho J Lehtimäki
Department of Clinical Chemistry, Tampere University Hospital
Tampere, Finland
Department of Medical Biochemistry, University of Tampere Medical School
Tampere, Finland
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Teemu Takala;
Teemu Takala
Department of Clinical Chemistry, Tampere University Hospital
Tampere, Finland
Department of Medical Biochemistry, University of Tampere Medical School
Tampere, Finland
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Jorma S A Viikari;
Jorma S A Viikari
Department of Medicine
Turku
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Juhani Knuuti
Juhani Knuuti
Turku PET Center, University of Turku
Turku
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Address correspondence and reprint requests to Olli-Pekka Pitkanen, MD, Department of Medicine, Turku University Central Hospital, Kiinamyllynkatu 4-8, FIN-20520 Turku, Finland. E-mail: opapitka@netti.fi
Diabetes 1998;47(2):248–254
Article history
Received:
June 24 1997
Revision Received:
October 01 1997
Accepted:
October 01 1997
Citation
Olli-Pekka Pitkänen, Pirjo Nuutila, Olli T Raitakari, Tapani Rönnemaa, Pertti J Koskinen, Hidehiro Iida, Terho J Lehtimäki, Hanna K Laine, Teemu Takala, Jorma S A Viikari, Juhani Knuuti; Coronary Flow Reserve Is Reduced in Young Men With IDDM. Diabetes 1 February 1998; 47 (2): 248–254. https://doi.org/10.2337/diab.47.2.248
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