Insulin resistance or compensatory hyperinsulinemia has been associated with hypertension and dyslipidemia in cross-sectional studies. In contrast, evidence from prospective population-based studies, which could establish the time order of the relationship, is sparse and inconsistent. Therefore, we investigated the associations of hyperinsulinemia with the incidence of hypertension and dyslipidemia in the Kuopio Ischemic Heart Disease Risk Factor Study, a population-based 4-year follow-up study of middle-aged men from eastern Finland. Out of 975 men who had no diabetes, 543 had resting systolic blood pressure (sBP) of <165 mmHg and resting diastolic blood pressure (dBP) of <95 mmHg at baseline and were not taking antihypertensive medication, and 764 had serum triglycerides of <2.3 mmol/l and HDL cholesterol of ≥1.0 mmol/l at baseline. In logistic regression models adjusted for age, baseline resting blood pressure, baseline lipids, obesity, weight change, and other risk factors, men with hyperinsulinemia (fasting insulin in the highest quintile, ≥12.0 mU/1) at baseline had a 2.0- fold (95% CI 1.1–3.5, P = 0.025) incidence of hypertension (sBP of≥165 or dBP of ≥95 mmHg), a 2.1-fold (95% CI 1.3–3.4, P = 0.002) incidence of dyslipidemia (serum HDL cholesterol of <1.0 mmol/l or serum triglycerides of ≥2.3 mmol/l), and a 2.6-fold (95% CI 1.1–6.3, P = 0.028) incidence of the combination of these disorders in 4 years, compared with normoinsulinemic men. These findings demonstrate the role of hyperinsulinemia in incident hypertension and dyslipidemia and suggest that both hypertension and dyslipidemia are associated with insulin metabolism disturbance, independently of obesity and body weight.
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Epidemiology|
February 01 1998
Hyperinsulinemia Is Associated With the Incidence of Hypertension and Dyslipidemia in Middle-Aged Men
Jukka T Salonen;
Jukka T Salonen
Research Institute of Public Health and Department of Public Health and General Practice, University of Kuopio
Kuopio, Finland
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Timo A Lakka;
Timo A Lakka
Research Institute of Public Health and Department of Public Health and General Practice, University of Kuopio
Kuopio, Finland
Department of Medicine, University Hospital of Kuopio
Kuopio, Finland
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Hanna-Maaria Lakka;
Hanna-Maaria Lakka
Research Institute of Public Health and Department of Public Health and General Practice, University of Kuopio
Kuopio, Finland
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Veli-Pekka Valkonen;
Veli-Pekka Valkonen
Research Institute of Public Health and Department of Public Health and General Practice, University of Kuopio
Kuopio, Finland
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Susan A Everson;
Susan A Everson
Department of Epidemiology, School of Public Health, University of Michigan
Ann Arbor, Michigan
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George A Kaplan
George A Kaplan
Department of Epidemiology, School of Public Health, University of Michigan
Ann Arbor, Michigan
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Address correspondence and reprints requests to Prof. Jukka T. Salonen, Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland. E-mail: [email protected]
Diabetes 1998;47(2):270–275
Article history
Received:
April 14 1997
Revision Received:
October 15 1997
Accepted:
October 15 1997
PubMed:
9519724
Citation
Jukka T Salonen, Timo A Lakka, Hanna-Maaria Lakka, Veli-Pekka Valkonen, Susan A Everson, George A Kaplan; Hyperinsulinemia Is Associated With the Incidence of Hypertension and Dyslipidemia in Middle-Aged Men. Diabetes 1 February 1998; 47 (2): 270–275. https://doi.org/10.2337/diab.47.2.270
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