Type 2 diabetes and the insulin resistance syndrome have been hypothesized to constitute manifestations of an ongoing acute-phase response. We aimed to study an interleukin-6 (IL-6) gene polymorphism in relation to insulin sensitivity (IL-6 is the main cytokine involved in an acute-phase response). Subjects homozygous for the C allele at position -174 of the IL-6 gene (SfaNI genotype), associated to lower plasma IL-6 levels, showed significantly lower integrated area under the curve of serum glucose concentrations (AUCglucose) after an oral glucose tolerance test, lower blood glycosylated hemoglobin, lower fasting insulin levels, lower total and differential white blood cell count (a putative marker of peripheral IL-6 action), and an increased insulin sensitivity index than carriers of the G allele, despite similar age and body composition. A gene dosage effect was especially remarkable for AUCglucose (6.4 vs. 9.3 vs. 9.7 mmol/l in C/C, C/G, and G/G individuals, respectively). The serum concentration of fully glycosylated cortisol binding globulin (another marker of IL-6 action), suggested by concanavalin A adsorption, was lower in C/C subjects than in G/G individuals (32.6+/-2.9 vs. 37.6+/-4.6 mg/l, P = 0.03). In summary, a polymorphism of the IL-6 gene influences the relationship among insulin sensitivity, postload glucose levels, and peripheral white blood cell count.
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March 01 2000
Interleukin-6 gene polymorphism and insulin sensitivity.
J M Fernández-Real;
J M Fernández-Real
Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain. endocrino@htrueta.scs.es
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M Broch;
M Broch
Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain. endocrino@htrueta.scs.es
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J Vendrell;
J Vendrell
Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain. endocrino@htrueta.scs.es
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C Gutiérrez;
C Gutiérrez
Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain. endocrino@htrueta.scs.es
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R Casamitjana;
R Casamitjana
Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain. endocrino@htrueta.scs.es
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M Pugeat;
M Pugeat
Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain. endocrino@htrueta.scs.es
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C Richart;
C Richart
Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain. endocrino@htrueta.scs.es
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W Ricart
W Ricart
Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain. endocrino@htrueta.scs.es
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Citation
J M Fernández-Real, M Broch, J Vendrell, C Gutiérrez, R Casamitjana, M Pugeat, C Richart, W Ricart; Interleukin-6 gene polymorphism and insulin sensitivity.. Diabetes 1 March 2000; 49 (3): 517–520. https://doi.org/10.2337/diabetes.49.3.517
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