Dr. Ricketts, Members of the Association and Guests: I am indeed highly honored that this Society has selected me, one who long since abandoned the bedside for the laboratory, to give the Banting Lecture. I am happy to join with this Association to pay tribute to a great physician whose discovery of insulin has done so much to diminish suffering in man. Outstanding discoveries in the field of medical therapy are rare. We count surgical asepsis, anesthetics, and antibiotics among the important ones. The imperishable studies of Banting and Best added insulin to these. Its discovery generated problems in many areas of medicine and these have aroused the imagination and stimulated the activities of scientists all over the world. Driven by insatiable intellectual curiosity, they have labored indefatigably to search out the mode of action of insulin upon mammalian metabolism. Although obscurity still darkens the field, these researches reveal a pattern which begins to have meaning. I have undertaken the task in this hour to describe this pattern as I see it.

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