Response to Comment on: Soranzo et al. Common Variants at 10 Genomic Loci Influence Hemoglobin A_1C Levels via Glycemic and Nonglycemic Pathways. Diabetes 2010;59:3229–3239

We read with interest the letter by Corcoy (1) with regards to our recent article in Diabetes (2). In this article, we calculated net reclassification using the approach of Pencina et al. (3). We counted the proportion of undiagnosed diabetic individuals with unadjusted HbA_1c ≥6.5% who had a 7-single nucleotide polymorphism (SNP)-adjusted HbA_1c <6.5%, and the proportion of nondiabetic individuals with unadjusted HbA_1c <6.5% who had a 7-SNP-adjusted HbA_1c ≥ 6.5%. The difference between these proportions is called “net reclassification” and in this instance indicates the overall proportion of a population whose diagnostic status would change based on the influence of the seven nonglycemic genetic variants that we identified.