CANA and GLP-1s have demonstrated weight loss (WL) in patients with type 2 diabetes mellitus (T2DM) in clinical trials. We compared the effects of CANA vs. GLP-1s on BW outcomes in routine practice using claims and electronic health record data from the U.S. Optum integrated database for adults with T2DM and ≥1 prescription claim for CANA or any GLP-1 from 1/1/13-3/31/15. BW outcomes and achievement of clinically significant WL ≥5% were assessed in matched patients with both ≥1 BW measurement during baseline (BL) and >31 days post-index. Inverse probability of treatment weighting (IPTW) accounted for differences in BL covariates. Weighted Cox regression was used to examine the hazard ratio (HR) and 95% confidence interval (CI) of WL ≥5%. After IPTW, covariates were balanced between cohorts except for BL BMI (CANA: n = 213; GLP-1: n = 235). Significant differences in BW were seen in the CANA vs. GLP-1 cohort over 9 months of follow-up (Figure). CANA cohort patients were more likely to achieve WL ≥5% (HR 1.93; 95% CI: 1.40-2.66) with a significantly longer duration at WL ≥5% (133 vs. 103 days; P = 0.01) than GLP-1 cohort patients.
In summary, superior WL of >9 kg at 9 months, >17% more patients achieving WL ≥5%, and longer duration of WL ≥5% as seen in the CANA vs. GLP-1 cohort may have important clinical implications due to links between BW reduction and other clinical/economic outcomes.
C.I. Coleman: Research Support; Self; Janssen Pharmaceuticals, Inc., Boehringer Ingelheim Pharmaceuticals, Inc. W.H. Herman: Other Relationship; Self; Merck Sharp & Dohme Corp., Lexicon Pharmaceuticals, Inc.. Consultant; Self; Janssen Scientific Affairs, LLC.. Research Support; Spouse/Partner; Nestlé. Other Relationship; Self; American Diabetes Association. Advisory Panel; Self; National Committee for Quality Assurance (NCQA). S. Pandya: Other Relationship; Self; Janssen Scientific Affairs, LLC. L. Wang: Other Relationship; Self; Janssen Scientific Affairs, LLC.. O. Baser: None. J. Cai: Employee; Self; Janssen Scientific Affairs, LLC. B. Bookhart: Employee; Self; Janssen Scientific Affairs, LLC..