With the diabetes epidemic spreading across Africa, undiagnosed diabetes threatens health. As the reproducibility of the OGTT in Africans is not known, the value of using the OGTT to diagnose diabetes (DM) in Africans is uncertain. Therefore, the Africans in America study enrolled 62 blacks (71% male, age 40±11y (mean±SD), BMI 27.8±4.6 kg/m2) who were born in Africa, identified as healthy and currently live in the Washington, DC area. Two OGTT were performed with 11±9 days between tests. The OGTT was used to define normal glucose tolerance (NGT), prediabetes (preDM) and DM. For reproducibility, the κ statistic was used and interpreted by conventional standards (slight 0.00 to 0.20, fair 0.21 to 0.40; substantial 0.61 to 0.80, excellent 0.81 to 1.0). At the 1st OGTT, NGT, preDM and DM were diagnosed in 40%, 26% and 34% of Africans, resp. At the 2nd OGTT, NGT, preDM and DM were diagnosed in 40%, 32% and 27%, resp. When all 3 glucose tolerance categories were considered, the κ statistic was 0.76. Dividing the cohort into 2 groups (with and without DM), the κ statistic increased to 0.85. Furthermore, no one diagnosed with DM on the first 1st OGTT was diagnosed with NGT on the 2nd OGTT (Table). In addition, no one without DM on the 1st OGTT was diagnosed with DM on the 2nd OGTT (Table). Based on data from Africans living in America, the OGTT is highly reproducible for the detection of DM.
S.M. Briker: None. J. Kabakambira: None. R.L. Baker: None. C. DuBose: None. L. Mabundo: None. S.T. Chung: None. J.N. Utumatwishima: None. A.E. Sumner: None.
