Emerging evidence suggests that adiponectin secreted into the serum by adipocytes may be involved in the development of type 2 diabetes. In addition, some cross-sectional studies have suggested that adiponectin may be related to PreD (prediabetes). Thus, it is reasonable to expect that adiponectin may play a role in PreD development. However, there are still few prospective cohort studies, which could successfully demonstrate a causative relationship between adiponectin and PreD. The aim of this study was to establish the significance of Adipo (serum total adiponectin level) as a biomarker for PreD in Japanese workers. To this end, we analyzed data in our prospective occupational-based cohort study, which has been conducted since 2008. A total of 551 workers without PreD aged 20-60 years were followed-up (mean follow-up period 4.2 years). The subjects were divided into four categories based on the quartiles of baseline Adipo for each sex (male: < 4.9, 4.9-6.6, 6.7-8.9 and > 8.9 µg/ml, female: < 8.2, 8.2-11.1, 11.2-13.9 and > 13.9 µg/ml). The age- and sex-adjusted incidence of PreD significantly increased with decreasing quartile of Adipo at baseline (P for trend <0.001). In multivariate analyses after adjusting for age, sex, BMI, smoking habit, alcohol intake, regular exercise, HDL cholesterol, triglycerides, family history of diabetes, and hypertension, the hazard ratio of PreD was 1.64 [95% confidence interval: 1.to 2.51, P=0.02] in the second quartile and 1.33 [95% confidence interval: 0.83 to 2.11, P=0.24] in the lowest quartile, when compared with the highest quartile. Furthermore, the risk of PreD was 5% higher (P=0.04) with a per 1 µg/ml decrement of Adipo in the multivariate-adjusted model. These results suggest that decreased Adipo is a risk factor for the incidence of PreD in Japanese workers, which could assign a new role to Adipo as a biomarker for the early stage of glucose homeostasis disorders, besides being a biomarker for the development of diabetes and cardiovascular events.
A. Hata: None. M. Miyoshi: None. T. Nakao: None. T. Ichihara: None. A. Tamura: None. T. Minagawa: None. Y. Kuwamura: None. M. Funaki: Research Support; Self; Otsuka Holdings Co., Ltd., The Knowledge Cluster from the Ministry of Education, Science, and Culture of Japan. Board Member; Self; Mechanogenic C.C..