Background: Vascular complications are the main cause of death and disability in people with type 2 diabetes (T2D). We assessed the occurrence of complication during the first year of follow-up of DISCOVER, a global, observational study of patients with T2D initiating second-line glucose-lowering therapy.

Methods: Patients with data available at 6 or 12 months were included. Microvascular complications comprised new diagnoses or procedures related to retinopathy, neuropathy, nephropathy or erectile dysfunction. Macrovascular complications comprised new diagnoses or procedures related to coronary or peripheral artery disease or heart failure.

Results: In 11 430 patients from 34 countries, new microvascular and macrovascular complications were reported in 6.6% and 4.7% of patients, respectively, with substantial variations across countries (Figure). The proportion of patients with new microvascular complications was higher in those with vs. without microvascular disease at baseline (9.8% vs. 5.9%, p < 0.001). The same was observed for new macrovascular complications in patients with vs. without macrovascular disease at baseline (16.9% vs. 2.9%, p < 0.001).

Conclusions: Rates of new vascular complications over 1 year were strikingly high in presumably low-risk patients with short T2D duration, highlighting opportunities for early aggressive risk-factor modification.

Disclosure

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