Objective: Changes in C-peptide index (CPI) before and after hemodialysis (HD) were compared to explore factors associated with insulin resistance in diabetic patients receiving HD.
Methods: Fasting blood samples were drawn from type 2 diabetic patients receiving maintenance HD but not insulin therapy at our clinic before HD on the first day of the week they went on HD (pre-HD) as well as on the next day (post-HD) and CPI was calculated.
Results: The mean post-HD CPI was significantly lower than the mean pre-HD CPI (6.7 ± 2.7 ng/mL vs. 8.1 ± 3.3 ng/mL) in the 19 type 2 diabetic patients (men/women, 12/7) included in the study. The rate of decrease in CPI was strongly positively correlated with geriatric nutritional risk index (GNRI) (R2 = 0.692) in these patients, while it was not correlated with their glycoalbumin (GA) or fasting glucose values.
S. Funakoshi: None. J. Hashiguchi: None. M. Hayashida: None. R. Etoh: None. K. Sawase: None. Y. Mori: None. K. Utsunomiya: None. T. Harada: None.