We previously showed that exposure to maternal diabetes mellitus (DM) affects adiposity and cardiovascular (CV) markers in pre-pubertal children. After further follow-up, we are now testing whether DM exposure continues to affect these markers throughout adolescence. Data on 381 youth (313 unexposed, 68 exposed) were collected at two research visits, on average at 10.4 and 16.6 years, respectively. Measures included BMI, waist circumference, height, visceral (VAT) and subcutaneous adipose tissue (SAT), systolic and diastolic blood pressure and fasting lipid levels. Linear mixed models were used to assess the longitudinal relationship between DM exposure and offspring outcomes, adjusting for child age, sex, race/ethnicity, and Tanner stage. BMI, VAT and SAT were log-transformed. We tested for effect modification of exposure by visit. Exposure to DM was associated with markers of adiposity and CV risk throughout adolescence (Table), and for most outcomes effects were not different across visits. Youth exposed to DM had higher non-HDL cholesterol at the second visit (β=0.30, p<0.001), but not at the first visit (03B2;=0.12, p003C;0.23) (interaction p<0.045). Adjustment for SES, child’s total calories and physical activity did not influence the results. Our data provides novel evidence that exposure to maternal DM has persistent effects on offspring adiposity and CV markers throughout adolescence.
C. Hockett: None. A.P. Starling: None. A. Bellatorre: None. J. Aalborg: None. K.A. Sauder: None. K. Garg: Research Support; Spouse/Partner; Eli Lilly and Company, MannKind Corporation. Advisory Panel; Spouse/Partner; Novo Nordisk A/S, Sanofi, Senseonics. Research Support; Spouse/Partner; Dexcom, Inc., Medtronic. B. Ringham: None. D.H. Glueck: None. D. Dabelea: None.
