Aim: This project aims to study differences in diffusion properties of the human calf muscle in subjects with and without type 2 diabetes mellitus (DM) using diffusional properties of water molecule.
Methods: Twenty-one subjects were examined in a 3T MRI scanner after obtaining consents. Two groups were tested: 8 participants without DM (WDM) and 13 participants with DM. We used a custom-made MRI compatible ergometer that allows a constant exercise load. Finally, we calculated diffusion indices including fractional anisotropy (FA), mean diffusivity (MD), and eigenvalues (λ1, λ2, λ3) for further analysis.
Results: Statistical analysis revealed no significant differences (P>0.05) in diffusion indices of muscles between WDM and DM at the rest position. However, all the muscles in DM showed (Figure) an overall statistically significant increase (P<0.05) in MD, λ2, and λ3 in response to exercise, in comparison with the WDM (MD= 15.02%; λ2= 16.50%; λ3= 14.22% for the MG).
M. Edalati: None. C.J. Sorensen: None. M. Hastings: None. M.A. Zayed: None. M.J. Mueller: None. J. Zheng: None.