Diabetes mellitus (DM) is one of the most familiar chronic diseases threatening human health. Studies showed the occurrence and development of type 2 diabetes mellitus (T2DM) are closely related to obesity. Obesity gives rise to higher level expression of inflammatory cytokines, which activate the inflammatory signaling pathway and suppress the insulin signaling transduction, thus lead to insulin resistance. Management of obesity is beneficial for improving T2DM, and the innate lymphoid cells (ILCs) play an important role in obesity as well as T2DM. Group 2 innate lymphoid cells (ILC2s) could regulate fat metabolism, while Group 3 innate lymphoid cells (ILC3s) and their secreted IL-22 are capable for suppressing inflammation and reducing insulin resistance. The Berberine (BBR), an extractive of coptis chinensis, has been verified that had certain hypoglycemic effect. In this study, We used high fat diet (HFD)-induced diabetes model, and observed an effective weight control, reduced blood glucose and lower insulin level after mice were fed with exogenous BBR. Further studies showed that the proportion of ILC3s was increased and the expression of IL-22 was up-regulated in the small intestine. Meanwhile, the proportion of ILC2s and expression of IL-4, IL-5 and IL-13 was also increased in the adipose tissue. In short, the BBR might affect glycolipid metabolism through regulating the differentiation and function of ILCs in the fat or intestinal mucosa.

Disclosure

X. Tong: None. X. Guo: None. L. Zhao: None. Z. Gao: None. L. Fu: None. X. Wang: None. Q. Li: None. Y. Zheng: None.

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