Background: We investigated the occurrence of microvascular lesions in nondiabetic offspring of parents with T2DM enrolled in the PROP-ABC (Pathobiology and Reversibility of Prediabetes in A Biracial Cohort)* study.

Design and Methods: We assessed albumin:creatinine ratio (MCR), vibration perception threshold (Vibratron II, Physitemp Instruments Inc, Clifton, NJ) and nonmydriatric retinal images (Zeiss digital camera, Carl Zeiss Meditec AG, Jena, Germany).

Results: There were 223 subjects (117 black, 106 white; 70% female), of whom 122 had prediabetes (impaired fasting glucose or impaired glucose tolerance) and 101 had normal glucose regulation (NGR; FPG <100 mg/dl and 2hrPG<140 mg/dl). The mean (± SD) age was 53.3 ± 9.1 years. Retinal lesions were found in 24 subjects (10.8% of the cohort), comprising macular changes (n=9), optic disc changes (n=8), epiretinal membrane (n=6), diabetic retinopathy (n=4), and vitreous opacities (n=2). The frequency of any retinal lesion was 12.3% vs. 8.9% among prediabetic vs. NGR subjects. The mean MCR was 9.95±2.1 ug/g among subjects with normal retina vs. 16.6 ±9.89ug/g among those with retinal lesions. There was a strong correlation between albuminuria and presence of retinal lesions (r=0.42, P<0.0001). The index finger vibration amplitude was 0.56 ±0.31 microns in prediabetic subjects vs. 0.43±0.25 microns in NGT subjects (P=0.013).

Conclusions: We here demonstrate a significant association between albuminuria and diverse retinal lesions in a biracial cohort of nondiabetic subjects, and further show relative impairment of vibration perception in prediabetic subjects (NCT02027571).


N.A. Umekwe: None. I. Owei: None. S. Dagogo-Jack: None.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at