Comparison of Cognitive Function, Depression, and Sleep Quality among Type 2 Diabetes Mellitus Patients With and Without Diabetic Neuropathy

Diabetic neuropathy is one of the most common complication of diabetes mellitus. Many studies had reported that type 2 diabetes mellitus increases the risk of cognitive impairement,depression and sleep impairement in patients with diabetes mellitus.

The main objective of the study is to determine whether any significant impairement in cognition function, sleep quality and depression status exist among diabetic neuropathy patients compared to patients with type 2 diabetes mellitus alone. A prospective observational study was conducted in a tertiary care teaching hospital. Patients who satisfied both inclusion and exclusion criteria were included in the study. A total of 59 type 2 diabetes mellitus patients with neuropathy and 55 patients with out neuropathy were enrolled in to the study after obtaining written informed consent. Cognitive status was assessed with the help of MOCA questionnaire. Sleep quality was assessed by using pittsburgh sleep quality index questionnare and depression, by using PHQ-9 questionnaire. The diabetic neuropathic patients showed a significant impairement in cognitive status (P value 0.003), sleep quality (P value 0.000) and depression status (p value 0.000). The study concluded that diabetic neuropathy increases the risk of cognitive impairement, impairement in sleep quality and depression in type 2 diabetes mellitus patients.