Our previous study showed that short-term intensive insulin therapies (SIIT) can improve insulin resistance by eliminating glucolipotoxicity and induce remission in newly diagnosed T2DM patients. It's interesting that smokers seem to recover worse than non-smokers. The purpose of this study is to clarify the effect of smoking on T2DM remission from SIIT. 103 male patients (aged 47±10 ys, HbA1C 11.2±2.1%, 59 smokers) after 2-week SIIT therapy were studied. At the 1-year follow-up, the remission rate was much lower in the smokers than non-smokers (36/59 vs. 35/44). Though their insulin secretion and HbA1C were similar at the end of therapy, the smokers have statistically higher TG and worse HOMA-IR. These results indicated that smoking might affect the remission rate mainly by the weaker improved metabolism of lipids.


X. Wan: None. Z. Huang: None. L. Liu: None. Y. Li: None.

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