Chronic life stress and “allostatic load” may increase risk for MetSyn. This study examines the associations between MSC, prediabetes, and MetSyn components in adolescents with body mass index (BMI) ranging from underweight to obese. Fasting blood was drawn ∼8AM from 191 healthy adolescents (126F/65M; 16.4±0.6 years; 95% Latino) to measure MSC, glucose, HbA1C, and lipids; triplicate measurements of BMI, waist circumference, and systolic/diastolic blood pressure (BP). All analyses were adjusted for a priori covariates of age, sex, BMI, and ethnicity. MSC was higher in adolescents with prediabetes (fasting glucose 100-125 mg/dL, n=20) vs. normoglycemia (Figure). This relationship was not seen when applying the prediabetes definition of HbA1C 5.7-6.4%. Higher MSC was associated with higher fasting glucose (β=0.02±0.005, p<0.001) and triglycerides (β=0.06±0.02, p=0.003). MSC was not associated with waist circumference, HDL cholesterol, HbA1c, or systolic/diastolic BP in linear modeling. However, adolescents with borderline/high BP (n=27) exhibited higher MSC compared to those with normal BP (516±32 vs. 392±12 nnol/L, p<0.001). The significant relationships between MSC, prediabetes and other MetSyn components suggest further study of the link between allostatic load and diabetes/cardiometabolic risk in adolescents is warranted.


C.M. Toledo-Corral: None. C.J. Lane: None. M. Weigensberg: None.


National Institutes of Health (R01AT008330)

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