1549-P: Factors Associated with Osteoporosis among Hospitalized Patients With and Without Diabetes

Background: Diabetes (DM) is a risk factor for osteoporosis (OP). Patients with DM are known to have a higher prevalence of periodontal disease (PD). The aim of this study was to determine factors associated with OP in a cohort of patients with and without DM and to see if there is any relationship with PD.

Method: We administered a questionnaire, inspected the dentition and conducted chart review of consecutive hospitalized patients to gather demographic information, dental health history, smoking history and history or presence of osteoporosis. Data was analyzed using T-tests, Chi-square tests and logistic regression models.

Result: Out of 301 patients enrolled, 102 had DM. Overall; the prevalence of PD was 91% and OP was 10%. In uni-variate analyses, factors significantly associated with diagnosis of OP included older age (p <0.001), female gender (p=0.046), having more discharge medications (p=0.01) and presence of DM (p=0.049). There was no significant relationship between PD or number of healthy teeth and OP. In logistic regression analyses including the significant factors associated with OP, age remained a significant predictor of having OP overall and in the non-DM population. However, in the DM population, female gender was the only significant predictor for having OP, after adjusting for age.

Conclusion: There was no significant relationship between having PD and OP, in our sample. Overall, age was the only significant predictor of having OP. In the DM group, female gender was a stronger predictor of having OP than age. Earlier screening for OP in female patients with DM may be useful to help identify OP sooner in this group.