Introduction: The aim of this study is to explore the relationship between hemoglobin level and the risk of glucose intolerance in Tibet residents.

Method: Eligible participants were aged from 20 to 80 years old, living in Tibet plateau for more than 3 months. The exclusion criteria were diagnosed diabetes, anemia or other hematological diseases, having been received transfusion in the past month. OGTT test was performed. Logistic regression and generalize additive models was used to explore the relationship between hemoglobin level and the risk of impaired glucose intolerance.

Result: A total of 818 people was enrolled in our research, including 586 (71.6%) male and 232 (28.4%) female. Participants were divided into normal group (Hb<210, n=747), and polycythemia group (Hb>210, n=71). There were 229 (30.66%) and 33 (46.48%) people were glucose intolerance in two groups separately (P<0.001). The odds ratio for male and female patients were 1.821 (95% CI 1.026-3.232) and 0.603 (95% CI 0.940-2.824), respectively. After stratified by sex, we find a “J” shaped relationship in male participants (Figure), and the turning point was 196g/L.

Conclusion: Elevated hemoglobin level is associated with increasing risk of glucose intolerance in male participants. When hemoglobin level is over 198g/L, the risk raised obviously as the hemoglobin level raising in male Tibet residents.

W. Suyuan: None. W. Yunhong: None. Z. Chenghui: None. L. Mingxia: None.

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