South Asians are at high risk for type 2 diabetes (T2DM). There is a paucity of data on prediabetes and T2DM incidence and related predictors in U.S. South Asians. We estimated prediabetes and T2DM incidence after five years of follow-up in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study (n=758) and examined the associated correlates. We defined T2DM and prediabetes using the ADA criteria. Prediabetes included isolated impaired fasting glucose (iIFG), isolated impaired fasting glucose (iIGT), and combined IFG+IGT. Overall, 482 (64%) individuals progressed, either from normal glucose tolerance (NGT) to prediabetes/T2DM, or from prediabetes to T2DM (Table 1). In standardized logistic regression models controlled for age and sex, only hepatic fat attenuation (OR: 0.69 (95% CI: 0.55, 0.87), visceral fat mass area (OR: 1.34 (95% CI: 1.05, 1.71), and hypertension (OR: 2.28 (95% CI: 1.49, 3.49) were associated with any glycemic progression. Hepatic fat attenuation was associated with progression from prediabetes to T2DM (OR: 0.56 (95% CI: 0.38, 0.82), and visceral fat mass area was associated with progression from NGT to prediabetes/T2DM (OR: 1.72 (95% CI: 1.23, 2.41). South Asians in the U.S. have a high incidence of dysglycemia. Hepatic fat attenuation may be a factor in the conversion from prediabetes to T2DM, and prevention efforts should target ectopic fat reduction.

U. Gujral: None. K. Narayan: None. N.R. Kandula: None. K. Liu: None. A.M. Kanaya: None.


National Institutes of Health (R01HL093009, K24HL112827, UL1RR024131)

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