The incidence and prevalence of type 2 diabetes mellitus (T2DM) vary in different regions and depend on several factors. Long-term nationwide epidemiological data are useful to assess trends over time. The aim of the study was to analyze the epidemiological changes of pharmacologically treated T2DM among adult patients in Hungary between 2001 and 2016. Annual incidence, prevalence and all-cause mortality rate of pharmacologically treated T2DM patients (age >18 years) were evaluated from 2001 to 2016. In our analyses we used the central database of the National Institute of Health Insurance Fund Management (Hungary). All data were anonymized at data export. Numbers are age-adjusted and standardized to European Standard Population at 2013. The number of incident cases with newly registered T2DM decreased from 76,645 (858 cases/100,000 person-years) to 29,122 (300 cases/100,000 person-years) resulting in an annual reduction of 11.6% (p<0.001) between 2001 and 2016. The number of prevalent cases continuously increased from 422,707 (4950 cases/100,000 person-years) to the highest number of 737,535 (8135 cases/100,000 person-years) in 2011, which plateaued during the next 3 years and slightly decreased thereafter. The standardized prevalence rate of T2DM increased by 60.5% in the investigated period. The prevalence rate of T2DM increased with increasing age; in 2016 it was ≥20% in patients with age of >60 years. All-cause mortality rate decreased between 2001 and 2016 by 11.8% from 2186/100,000 person-years to 1928/100,000 person-years. Despite a clearly decreasing incidence of pharmacologically treated T2DM in adult patients, the prevalence increased from 2001 to 2011 followed by a 3-year-long plateau and a slight decrease thereafter. These long-term trends with the reduced mortality rate may indicate favorable effects of health promotional activities for preventing and treating T2DM in the period of 2001-2016 in Hungary.
G. Jermendy: None. Z. Kiss: None. G. Rokszin: None. Z. Abonyi-Tóth: None. I. Wittmann: None. P. Kempler: None.