Intracellular magnesium contributes in the regulation of the effects of insulin and glucose uptake; its deficits strongly associated with hyperglycemia, hypertriglyceridemia and insulin resistance (IR). Studies in healthy, hypertensive, and diabetes mellitus type 2 (DM2) subjects have shown a lower concentration of intracellular magnesium, higher glucose increase. It is unknown if there is hypomagnesemia related to hyperglycemia and insulin resistance during pregnancy. Analytical cross-sectional study in pregnant women who signed consent, ≥18 years old, any trimester of pregnancy. Patients with chronic diarrhea, alcohol intake (≥30 g/day), use of diuretics and/or calcium channel blockers, reduced renal function, or supplemented with magnesium for at least six months prior to the study were not included. Clinical variables were determined, anthropometry, vital signs, serum magnesium levels, fasting glucose and 2-h plasma glucose (2-h PG) value during a 75-g oral glucose tolerance test (OGTT), lipid profile and glycosylated hemoglobin (A1C) were measured. We analyzed 84 patients with whom the 3 study groups were formed: healthy pregnant women, with IR (TyG index) and gestational diabetes (GD) (Table). Hypomagnesemia was found in all 3 groups without a clear relationship between low magnesium levels and alterations in glucose status.


A. López Castro: None. A. Zavalza Gomez: None. S. Hernandez Gonzalez: None. M.C. Espinel-Bermudez: None. J.R. Ortiz Hernandez: None.

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