Transcranial direct current stimulation (tDCS) of the right dorsolateral prefrontal cortex (DLPFC) may reduce appetite and caloric intake. However, it is used as an adjunct treatment for depression by stimulation of the left DLPFC. As a result, its safety in mental health and its impact on quality of life of subjects with excess weight needs to be addressed.

Objective: To assess the effect of repeated tDCS of the right DLPFC on mood, daytime sleepiness, anxiety and quality of life in subjects with excessive weight on a hypocaloric diet.

Methods: We randomly assigned 28 participants to receive 20 sessions of active or sham tDCS for 20 consecutive weekdays. Anode and cathode electrodes were respectively placed on the right and left DLPFC. The Beck Depression Inventory (BDI), a daytime sleepiness questionnaire (DSQ), State-Trait Anxiety Inventory-State (STAI-S) and the 36-Item Short Form Health Survey (SF-36) were administered before (t0) and after (t20) the intervention period.

Results: There were no statistically significant changes in BDI, DSQ, STAI-S and SF-36 subscales between the groups throughout the study (Figure 1A and 1B).

Conclusion: The absence of significant changes in the scales suggests that tDCS is not associated with impairment in mental health and quality of life in this population. NCT02683902.


G.R. Natividade: None. C. de Araujo: None. R.C. Fitz: None. A.F. Osório: None. P.N. Merello: None. P. Schestatsky: None. F. Gerchman: Speaker's Bureau; Self; Novo Nordisk Inc. Other Relationship; Self; Sanofi-Aventis.


Hospital de Clínicas de Porto Alegre (FIPE15-0119)

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