Aim: The objective of the study was to investigate whether higher serum urate (SUA) level has consistent association with cardiovascular disease (CVD), diabetic kidney disease (DKD) and diabetic retinopathy (DR) in Chinese adults with type 2 diabetes mellitus (T2DM).

Methods: 4,767 diabetic participants were enrolled from seven communities in Huangpu and Pudong District, Shanghai, China in 2018. Participants underwent several checkups, which included the measurement of anthropometric parameters, blood pressure, glucose, lipid profiles, SUA and urine albumin/creatinine ratio (ACR).

Results: Compared with the first SUA group, the third group increased the prevalence of CVD by 27% (OR 1.27; 95% CI 1.04, 1.55) (P for trend <0.05) and increased the prevalence of DKD by 88% (OR 1.88; 95% CI 1.48, 2.40) for KDOQI definition. Compared with first group, OR (95% CI) of DR ranging from non-retinopathy (NDR) to proliferative diabetic retinopathy (PDR) in ordinal logistic regression associated with SUA level was 0.81 (0.59, 1.10) for the third group, (P for trend=0.086) and OR (95% CI) of the number of diabetic complications ranging from 0 to 2 in ordinal logistic regression associated with SUA level was 1.75 (1.44, 2.12) for the third group (P for trend< 0.01). These associations were all full adjusted.

Conclusions: Higher SUA level was associated with increased odds of CVD, DKD and variety of the diabetic complications, not DR, in middle-aged and elderly diabetic Chinese adults, which means lowering SUA level may be critical for prevention and intervention of diabetic complications.

Disclosure

H. Wan: None. Y. Wang: None. Y. Chen: None. C. Wang: None. W. Zhang: None. F. Xia: None. N. Wang: None. Y. Lu: None.

© 2019 by the American Diabetes Association.
2019
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.