Hand grip strength (HGS) is widely used as a simple, inexpensive and non-invasive diagnostic parameter for frailty and sarcopenia. Low HGS in community-dwelling populations has been reported to predict a higher mortality risk. Whether this association is independent from the presence of type 2 diabetes (T2DM) and pre-existing coronary artery disease (CAD) is not known and is addressed in the present study. We prospectively recorded deaths over a mean follow-up time of 9.2±3.1 years in a cohort of 845 subjects in whom the baseline CAD state was determined angiographically. At baseline, HGS was higher in male than in female participants (41.5±10.3 vs. 24.0±5.06 kg; p<0.001); it did not differ significantly between patients with T2DM and nondiabetic subjects. Prospectively, low HGS predicted overall mortality both in men and women, with standardized adjusted HRs of 0.90 [0.83-0.99]; p=0.035 and HR 0.65 [0,50-0,82]; p<0.001 after multivariate adjustment including T2DM and the presence of CAD at baseline. We conclude that low hand grip strength predicts mortality independently from T2DM and the presence of CAD.
B. Larcher: None. A. Vonbank: None. C. Heinzle: None. D. Zanolin-Purin: None. A. Mader: None. A. Said: None. H. Drexel: None. C.H. Saely: None.