The lipoprotein insulin resistance index (LPIR) is an emerging biomarker that correlates with peripheral insulin resistance (IR) derived from a composite score of 6 nuclear magnetic resonance (NMR) lipoprotein (LP) parameters. However, its ability to reflect hepatic and total body IR in women of African descent, who have low-normal triglyceride-rich LP particles, is unclear. Our objectives were to compare LPIR in black (BW) and white (WW) women and determine the association with insulin sensitivity index (SI), hepatic insulin sensitivity index (HISI), and hepatic and visceral fat content. In 127 federally employed women without diabetes (78 BW and 49 WW; age 44±10 (24-62y); BMI 30.2±5.7 (20.3-45.2 kg/m2); mean±SD (range)), LPIR was derived, SI was calculated by the minimal model, basal HISI using stable isotopes and hepatic and visceral fat measured by proton NMR. LPIR was lower in BW (18 (8-37) vs. 26 (14-41), median (IQR), P=0.04) but there was no difference by race in the correlation coefficients of LPIR with SI (r=-0.5), HISI (r=-0.6), hepatic fat (r=0.5), visceral fat (r=0.6), all P<0.01. Compared to the 1st quartile, the 4th quartile of LPIR was associated with lower hepatic and total IR, and higher hepatic and visceral fat (Table). Overall, the LPIR index was a strong correlate of hepatic and total IR and may be a useful index for identifying individuals who are at risk for diabetes.
C.K. Cravalho: None. A.G. Meyers: None. L. Mabundo: None. A.E. Sumner: None. S.T. Chung: None.
National Institute of Diabetes and Digestive and Kidney Diseases