2495-PUB: Negative Relationship between Obesity and Cardio Ankle Vascular Index in Diabetic Patients

Introduction: The aim of this study is to explore the relationship between obesity and cardio-ankle vascular index (CAVI) in Tibet diabetic patients.

Method: Related data of hospitalized diabetic patients during May 2017 to November 2018 were collected and analyzed. Eligible patients were diagnosed diabetic patients aged from 18 to 80. The exclusion criteria were malignant tumor, patients who has been undertaken surgery in the past 6 months. Logistic regression was used to analyze the relationship between CAVI and Obesity.

Result: A total of 1025 patients were enrolled, 758(73.95%) were female. Patients were divided into 3 groups according their BMI, 335 patients were normal in weight(BMI≤24kg/m2), 463 were overweight(24kg/m2≤BMI≤28kg/m2) and 227 were obesity(BMI≥28kg/m2). The age of these patients were 54.81±9.6. CAVI among three groups were 8.58±1.12, 8.34±1.16, 8.12±1.2, respectively (P<0.001). After adjustment for age, gender, SBP, DBP, and duration of diabetes, BMI was negatively associated with CAVI (β=-0.067, 95% CI -0.090∼-0.059, P<0.001), CAVI was lower in overweight (β=-0.265, 95% CI -0.382∼-0.147, P<0.001)and obesity (β=-0.558, 95% CI -0.702∼-0.413, P<0.001) groups. We also found a negative relationship between waist circumference(β=-0.020, 95% CI -0.025∼-0.014, P<0.001), abdominal obesity (β=-0.369, 95% CI -0.494∼-0.245, P<0.001), and CAVI.

Conclusion: We found a negative relationship between BMI and CAVI in diabetic patients, further study is required to find out possible mechanism and its influence on the onset of CVD.