Based on the set glucose thresholds for hypoglycemia alarms, continuous glucose monitoring (CGM) systems can provide audible alerts that notify individuals for actual/impending hypoglycemic events. While CGMs have been shown to reduce hypoglycemic events in patients with type 1 diabetes (T1D), there are little data demonstrating the association between glucose thresholds for hypoglycemia alarms and clinical hypoglycemia outcomes. This cross-sectional observational study enrolled 83 T1D patients with CGM use >3 months, active CGM usage time ≥70% and activated (i.e., turned “on”) hypoglycemia alarms. CGM settings and two-week CGM glucose data (total 25,683 hours) were analyzed. Glucose thresholds for hypoglycemia alarms (mean: 74 ± 8 mg/dL; range: 60-100 mg/dL) correlated inversely with time in hypoglycemia (both glucose <54 and <70 mg/dL) (Figure 1a). When comparing the cohort with hypoglycemia alarm threshold settings at glucose level ≤70 mg/dL (n=42), threshold settings ≥75 mg/dL (n=41) were associated with a 74% and 60% reduction in hypoglycemia time (<54 and <70 mg/dL, respectively) (Figure 1b). All subjects with hypoglycemia alarm set at glucose ≥75 mg/dL spent less than 3% of time with glucose <54 mg/dL. The current data support the use of higher glucose thresholds on CGM hypoglycemia alarms to decrease the time in hypoglycemia in patients with T1D.

Disclosure

Y. Lin: None. M. Hung: None. A. Sharma: None. O. Chan: Research Support; Self; Zucara Therapeutics Inc. M. Varner: None. D. Groat: None. D. Dopita: None. S. Fisher: None.

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