Objective: Vascular lesions caused by type 2 diabetes (T2DM) is unquestionable, but the relationship with serum 25-hydroxyvitamin D (25(OH)D) is controversial. Our study intends to analyze the association between the vascular disease of T2DM and the level of 25(OH)D.
Methods: A total of 576 patients with T2DM and 532 healthy people in our hospital from 2016 to 2017 were enrolled. The level of 25(OH)D between T2DM group and non-DM group was compared. Patients with T2DM were divided into carotid intimal thickening group(472 cases, IMT>1.0mm) and normal carotid artery group(104 cases, IMT<1.0mm) by ultrasonography. According to whether hemorrhage or exudation in fundus photography, they were divided into microvascular disease group(226 cases) and non-microvascular disease group(350 cases). Furthermore, we analyzed the association between the level of 25(OH)D and clinical characters by SPSS22.0.
Results: The level of 25(OH)D in T2DM group was significantly lower than non-DM group(42.66±13.81 vs.66.00±11.53, P<0.001). Serum 25(OH)D concentration increased in carotid intimal thickening group(42.80±13.96 vs.42.07±13.16, P=0.626), but was lower in microvascular disease group(41.17±14.02 vs.43.63±13.60, P=0.036). Levels of HbA1c, FPG, FINS, FCP, Alanine aminotransferase, Aspartate aminotransferase, Creatinine, Uric acid, TC, TG, HOMA-IR in the low 25(OH)D group were higher than normal group, but HOMA-IS, HOMA-β were lower. Therein, levels of FPG(P=0.010), FCP(P=0.006), TC(P<0.001), TG(P<0.001), HOMA-IS(P=0.002)had significant difference. In addition, gender, age and duration of disease was not related to 25(OH)D.
Conclusion: The 25(OH)D in patients with T2DM is lower than healthy people and the incidence of microvascular disease is increased, but there is no definite correlation with macrovascular disease. In the T2DM population, supplementation of 25(OH)D may improve vascular lesions by regulating glycolipid metabolism, which needs further study.
N. Li: None. L. Xu: None. Y. Wang: None. S. Yang: None. P. Yang: None. J. Dong: None. H. Li: None. S. Qu: None.