Objective: This clinical study investigated the association between body composition and glycemic variability in Japanese type 2 diabetes patients.
Research Design and Methods: A total 34 Japanese type 2 diabetes out-patients were enrolled. Glycemic variability were assessed using continuous glucose monitoring (CGM) and we excluded the glycemic data within 24 hours after mounted. Their body composition were measured by Inbody 770 (Inbody Japan, Japan). Statistical analyses were done by SPSS ver.23 and the data were showed by mean±SD.
Results: Baseline characteristics are indicated thus; male/female 22/12, 68.4±10.2 years old, period of CGM measuring 11.1±2.8 days, height 1,61±0.08 m, body weight 64.3±13.3 kg, A1c6.9±0.8%, duration of diabetes 5.4±9.8 years, maximum glucose 256±56 mg/dl, minimum58±17 mg/dl, average 137±31 mg/dl, SD37.8±14.9 mg/dl, body muscle weight 42.2±8.6 kg, body fat weight19.2±7.3kg. The patients with hypoglycemia (less than 50 mg/dl) in CGM were significantly less body height (1.64±0.07 m vs. 1.57±0.08 m, P=0.012), less body weight (70±14.6 kg vs. 57.8±7.9 kg, P=0.005)and less amount of total body muscle (45.8±8.9 kg vs. 38.3±6.4 kg, P=0.009).The patients with glycemic SD more than 40 mg/dl were lighter weight(67.7±13.9 kg vs. 57.4±9.0 kg, P=0.033) and lower BMI (25.6±3.9 vs. 22.2±2.3, P=0.014). There were no significantly difference in body fat and muscle amount in each group. The patients who had more than 5% of duration time with more than 200 mg/dl were lower BMI (25.6±4.0 vs. 22.7±2.6, P=0.035)and less amount of total body muscle (44.6±9.3 vs. 37.9±5.8, P=0.018).In multiple regression analysis after adjustment by age, sex and BMI hyperglycemia was found be significantly associated with body muscle percentage and body fat percentage.(OR0.007 CI;0.000to0.791 P=0.040 OR0.010 CI;0.000to0.852 P=0.042, respectively).
Conclusions: The Japanese type 2 patients with less body muscle amount may tend to show higher glycemic variability.
A. Mizoguchi: None.