Objective: The purpose of this study is to evaluate if low muscle mass increases risk of T2D in women with previous gestational diabetes mellitus (pGDM).
Methods: A total of 378 women with pGDM (mean age: 35.6 ± 3.9 years) was prospectively evaluated for incidence of T2D. GDM was diagnosed with 75g or 100g oral glucose tolerance test (OGTT) during 24-28 week gestational age. Reclassification of glycemic status was performed with 75g OGTT at 2 months after delivery and lean body mass (LBM) was assessed with bioelectrical impedance analysis (Inbody720, Seoul, Korea). LBM was divided by BMI and this index was divided into 3 tertiles: lowest ≤0.88 (N=107), middle 0.89-0.97 (N=111), highest ≥0.98 group (N=99). The primary outcome was incidence of T2D up to 1 year follow up.
Results: The lowest muscle group developed T2D (p=0.007) more than higher muscle groups. The trend for risk developing prediabetes and T2D was significantly increased according to LBM/BMI tertiles (p for trend=0.002). After adjusting family history of T2D, extent of gestational hyperglycemia and waist circumference, lowest group demonstrated HR for developing T2D 6.6 [CI 1.36 to 32.25], p=0.01, compared to the highest group.
Conclusion: Lower muscle mass is an independent risk factor for T2D in pGDM. Therefore, it is important to examine muscle mass during risk assessment for T2D in Korean non-obese women with pGDM.
Y. Shin: None. T. Oh: None. S. Choi: None. H. Jang: Speaker’s Bureau; Self; Daiichi Sankyo, Handok, Pfizer Inc., Takeda Pharmaceutical Company Limited.
