Introduction: Acute pancreatitis (AP) is the most common reason for hospitalizations for gastrointestinal disorders in the United States. Diabetes mellitus (DM) is known to increase the risk for AP by almost 3-fold. Single center studies have demonstrated demographic disparities in AP patients with DM. The identification of AP and DM patients at risk may provide clues to etiology and develop population preventative measures to lower AP-related hospitalizations. Our primary aim was to evaluate demographic trends in patients with DM and AP using a large national database.

Methods: We extracted data from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample database, from 2012-2014. International Classification of Diseases 9th Version, and used clinical modification codes for adult patients hospitalized with primary diagnosis of AP.

Results: There were 1,310,385 primary admissions for AP during the study period. 27.4% were diagnosed with AP-DM. Patients with AP-DM were older in age compared to AP only (p<0.001). Majority of AP only patients were female (50.4%). Majority of patients with AP-DM were male (55.1% without complications and 50.7% with complications). Non-Hispanic Whites (NHW) had the highest prevalence of AP without DM. All other races had greater prevalence of AP-DM, including the largest discrepancy in African-Americans (AA) and Hispanics. For NHW, 67.6% did not have DM, 59.0% and 53.3% had DM without and with complications, respectively. For AA, 14.5% did not have DM, 18.8% and 24.4% had DM without and with complications, respectively.

Conclusions: This study is the first to demonstrate a racial disparity in AP patients with DM on a national scale. Patients with AP-DM were likely to be older, male, and AA compared to NHW, which is consistent with previous data. Multiple factors between NHW, AA and Hispanics which include but are not limited to genetic, socioeconomic, and cultural factors may be determinants of this disparity.


N. Choi: None. M.E. Garcia: None. B.L. Zakhary: None. M.A. Firek: None. D.I. Kim: None. C.S. Jackson: None. A. Firek: None.

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