Introduction: Trends in the prevalence of chronic kidney disease (CKD) and obesity in adults with type 1 diabetes have not been rigorously characterized. We hypothesized that, like the type 2 diabetes population, there have been increases in the prevalence of eGFR <60 ml/min/1.73 m2 (CKD) and body mass index (BMI) >30 kg/m2 (obesity) in the population with type 1 diabetes.
Methods: We conducted a retrospective analysis of 4215 patients in the Geisinger Health System (central Pennsylvania) with type 1 diabetes, defined using the validated Klompas algorithm. We constructed period prevalent cohorts within each calendar year from 2004 to 2018 and estimated the prevalence of CKD and obesity using average values within each calendar year.
Results: The 2004 cohort contained 530 people with type 1 diabetes; the 2018 cohort contained 1485 people. Percent female was 54.0% in 2004 and 50.4% in 2018; average age was 43.9 (SD, 16.1) and 48.1 (SD, 15.9), respectively. The prevalence of CKD was 14.7% in 2004 and 17.4% in 2018 (p-trend = 0.80) (Figure). The prevalence of obesity was 30.0% in 2004 and 38.9% in 2018 (p-trend =0.006). The average BMI was 27.6 (6.0) in 2004 and 29.1 (6.6) in 2018 (p-trend = 0.002). In associations adjusted for demographics, trends were similar.
Conclusions: The prevalence of obesity increased, but there was no change in the prevalence of CKD over the last 15 years among people with type 1 diabetes in a rural health care system.
A. Wallace: None. A.R. Chang: None. M. Grams: Other Relationship; Self; DCI. E. Selvin: None.
National Heart, Lung, and Blood Institute (T32HL007024)