Objective: Bile acids not only play roles in dietary lipid absorption and cholesterol homeostasis, but also regulate triglyceride, cholesterol, energy and glucose homeostasis. We aimed to investigate the change of bile acids after 12 weeks of internet derived low energy diet intervention in overweight and obesity participants.

Methods: This was a prospective observational study of 39 overweight and obesity participants. A calorie restricted diet (800-1200kcal/day) with high-intensity consultant was provided to all the participants. Plasma Bile acids were measured in baseline and after 12 weeks by high-performance liquid chromatography-mass spectrometry.

Results: The levels of bile acids before and after intervention are presented in Table. Except for taurocholic acid and taurochenodeoxycholic acid, there seems to be a downward trend for other bile acids after intervention. However, only the changes of chenodeoxycholic acid, lithocholic acid, and ursodeoxycholic acid had statistical significance. The level of conjugated bile acid was significantly increased and the conjugated/unconjugated bile acids ratio was decreased after intervention.

Conclusions: Participants undergoing calorie restricted diet showed changes in the level of conjugated bile acid and conjugated/unconjugated ratio. Further research is needed to see the relationship between these changes and clinical features.


C. Zhang: None.

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