In the United States, type 2 diabetes (T2D) has a disproportionate impact on underserved populations, and this appears to be related to excess weight. Although reasons are likely multifactorial, it is unclear if there are gender-related influences on obesity risk for these populations. We compared body habitus by gender for 218 adults [84% Mexican-American, 152 females, mean (SD) age 56.2 (10.7) years, HbA1c 8.1 (2.0) %, BMI 31.2 (6.7) kg/m2, 45% uninsured, 42% food insecure (U.S. Household Food Security Survey)] with T2D participating in 2 clinical trials (NCT03830840 and NCT03940300). Comparisons were made for BMI, waist circumference (WC), relative fat mass (RFM), systolic blood pressure (SBP), HbA1c, and food security by gender (Table). Results expressed as mean (SD), unless specified. Significant associations (Spearman’s Rho) were found between WC and BMI (rs= 0.82) and WC and RFM (rs=0.66, both p<0.001) for all participants and when stratified by gender (p<0.001). There were no significant associations between HbA1c and RFM or BMI, except for BMI and HbA1c in males (rs=-0.31, p=0.02). Food insecure adults had higher HbA1c (%) levels than those who were food secure (median [IQR] 7.65 [6.98-9.35] versus 7.30 [6.40-8.63], p=0.02).
In conclusion, gender may be an important influence on body habitus for underserved populations with T2D. Food insecurity is also common and can impact glycemic control.
W.C. Bevier: None. N.M. Glantz: Research Support; Self; Abbott, Eli Lilly and Company. A.J. Larez: Research Support; Self; Eli Lilly and Company. M.A. Kujan: None. C. Conneely: None. K.N. Castorino: Research Support; Self; Abbott, Dexcom, Inc., Medtronic, Mylan, Novo Nordisk Inc. D. Kerr: Advisory Panel; Self; Novo Nordisk A/S, Sanofi-Aventis. Research Support; Self; Eli Lilly and Company. Stock/Shareholder; Self; Glooko, Inc.
Eli Lilly and Company; U.S. Department of Agriculture (2018-01793)