The inflammatory processes that develop in patients with type 2 diabetes mellitus (T2DM) vary in different ethnic groups. The level of cytokines in the peripheral blood characterizes the severity of the disease and the dynamics of the pathological process in the acute period of myocardial infarction. The study included 34 individuals of the Buryat population. The Buryats are the main northern group of Mongolians, they are a core population of Siberia with a compact residence close to Lake Baikal. The first group included 14 patients with T2DM and ST-elevation acute myocardial infarction (STEMI) (5 men and 9 women), with a median age was of 62.5 years. The second group consisted of 20 individuals of the control group without diabetes and STEMI (11 men and 9 women), a median age was of 62 years. We studied levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α), high sensitivity C-reactive protein (hs-CRP) admitted within 24 h after the symptoms onset (Table 1). In Buryat patients with T2DM and STEMI, production of pro-inflammatory cytokines IL-1β and IL-6 relative to the control group without diabetes and STEMI (p <0.05) is reduced. In addition, in Buryat patients with T2DM and STEMI, a significant increase in the level of hs-CRP was registered relatively to the control group (p<0.05).
T. Bardymova: None. T. Belokhvostikova: None. S. Tsyretorova: None.
