Objective: To examine the prevalence of sarcopenia in type 2 diabetes (T2DM) patients and to clarify the associated risk factors.
Methods: T2DM patients aged 50 years or older were included from nine research centers. Body composition was measured by bioimpedance analysis. Sarcopenia was defined by low muscle strength coexisted with low muscle mass. Low muscle strength was determined by grip strength below the lower quintile of the same sex subjects, the cutoff was below 29.5kg in men and 21.2kg in women. Low muscle mass was determined by the appendicular skeletal muscle index (ASMI) below the lower quintile of the homogeneity, same sex and healthy young group, the cutoff value was 7.18kg/m2 in men and 5.73kg/m2 in women.
Results: (1)A total of 1125 participants including 586 males(52%) and 539 females(48%) was analyzed. The average age was (62.6±8.3) years, BMI was (25.8±3.4) kg/m2, the diabetes duration was [10.36(5.32, 16.15)] years, FPG was (8.4±2.5)mmol/l, and HbA1c was (8.1±1.8)%. There were no statistical differences between male and female. (2)The detection rate of low muscle mass was 14.0%, male was significantly higher than female(18.3% vs. 9.3%); (3)The detection rate of low grip strength was 36%, male was significantly higher than female (50.3% vs. 20.4%);(4) The prevalence of sarcopenia in all participants was 8.5%, male was significantly higher than female (12.8% vs. 3.9%). (5)Logistic regression analysis showed men, low BMI, aging, high HbA1c were risk factors associated with sarcopenia. The risk of sarcopenia increased obviously in patients older than 75 years old(OR=4.992, 95%CI 2.448-10.179) or whose HbA1c was over 10%(OR=3.563, 95%CI 1.526-8.322).
Conclusion: T2DM was associated with increased risk of sarcopenia. Low BMI, aging, high HbA1c were risk factors associated with sarcopenia in T2DM.
Q. He: None. L. Guo: None.