2316-PUB: Lipidomic Profiling Reveals Distinct Differences in Plasma Lipid Composition in Overweight or Obese Adolescent Students

The relationship between dyslipidemia and obesity has been widely reported, but the global lipid profiles associated with the development of obesity remain to be clarified, especially in the East Asia teenage population. We recruited 90 adolescent participants, including 30 individuals with normal body mass index (BMI) (BMI: 16-20), 30 obesity students (BMI: 20-26), and 30 overweight students (BMI: 26-37). All participants wereperformed anthropometric measurement by using InBody 770. Mass spectrometry coupled with liquid chromatography was applied to detect the global lipidome in the fasting plasma. Clinical biochemical indicators were measured by Cobas Elecsys 601. Both qualitative and quantitative analyses revealed a gradual change in plasma lipid features with obesity students exhibiting characteristics close to overweight students, but they differed significantly from students with normal. The levels of triglyceride, 18-Hydroxycortisol, Isohumulinone A, and 11-Dihydro-12-norneoquassin were up-regulated in obesity group, while phosphatidylcholine (PC), phosphatidylethanolamine (PE), LysoPC, LysoPE, and Phosphatidylinositol were significantly down-regulated in obesity group than in control and overweight individuals. Then conducted venn diagram and selected 8 significant metabolites from the 3 paired comparisons. Most of the selected features significantly correlated with anthropometric measurement.

In conclusion, the altered plasma lipidome in Chinese obesity and overweight students suggested that lipid features may provide a basis for evaluating risk and monitoring obesity development.