2319-PUB: Adipose Tissue Distribution Is Associated with the Risk of Stones in Patients with Type 2 Diabetes: A Cross-Sectional Study in China

Purpose: This study aims to investigate the correlation between adipose tissue distribution and the prevalence of gallstones and urinary stones in patients with type 2 diabetes.

Methods: A total of 2477 patients with type 2 diabetes (T2DM) admitted to the Third Affiliated Hospital from January 2016 to December 2018 were enrolled in the study. Each patient was subjected to physical examinations including measurements of height, body weight, waist circumference (WC), hip circumference (HC), standard biochemical tests and abdominal ultrasound measurement. Body mass index (BMI) and waist to hip ratio (WHR) were calculated. Patients were stratified into 4 quartiles based on WHR: ˂0.8817, 0.8817-0.9240, 0.9240-0.9574 and ˃0.9574.

Results: There is a significant association between abdominal obesity and increased risk of stones in T2DM patients. After adjusting with regular confounding factors, multivariate logistic regression analysis showed that T2DM patients at the 4^th quartile of WHR had a higher risk of gallbladder stones compared with patients in the 1st quartile (OR = 3.78, 95%CI:1.16-12.30, P = 0.027). Moreover, after adjusting for some confounding factors other than BMI, T2DM patients at 4^th quartile of waist-to-hip ratio also had a significantly higher risk of kidney stones than those in the 1^st quartile (OR=5.34, 95% CI: 1.14-25.01, P=0.033). However, after further adjusted for BMI, it was not significant.

Conclusion: T2DM patients with more severe abdominal obesity, i.e., the 4^th quartile of WHR, show a significantly increased risk of gallstones. We conclude that WHR is an independent risk factor for gallstone in T2DM patients.