Purpose: To evaluate the association between the biological disease-modifying anti-rheumatic drugs (bio-DMARDs) and the incidence of diabetes.

Methods: Studies recording the incidence of new-onset diabetes in subjects treated with bio-DMARDs were included.

Results: In total, 23 relevant studies were included. The pooled analysis suggested that bio-DMARDs treatment did not reduce the incidence of diabetes (RR= 0.87, 95% CI, 0.69 to 1.08, P = 0. 21) compared with non-bioDMARDs. However, subgroup analyses revealed incidence of new-onset diabetes was significantly reduced in patients with abatacept treatment (RR = 0.61, 95% CI, 0.38 to 0.99, P = 0.04).

Conclusions: The utilization of bio-DMARDs in general was not associated with the incidence of diabetes while the abatacept treatment may reduce the risk of diabetes.


C. Lin: None. H. Ji: None. X. Cai: None. W. Yang: None. L. Ji: None.


National Natural Science Foundation of China (81970698); National Key Research and Development Program of China (2016YFC1304901)

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