We investigated the role of peripheral perfusion as an indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease (CVD). This retrospective cohort study included 1080 patients with type 2 diabetes and history of CVD recruited from the outpatient clinic at Matsushita Memorial Hospital in Osaka, Japan. Peripheral perfusion is assessed using the perfusion index (PI), which represents the level of circulation through peripheral tissues. PI was measured using a Masimo SET Radical-7 (Masimo Corporation, Irvine, CA) instrument. The median age and PI values were 74 years (range: 67-79 years) and 2.6% (range: 1.1-4.3%), respectively. The average duration of follow up was 871 ± 265 days. During follow-up duration, 60 patients died due to CVD. The adjusted Cox regression analysis demonstrated that the risk of developing cardiovascular death was higher in the first quartile (HR, 5.84; 95% CI, 2.23 to 20.16) or second quartile (HR, 3.00; 95% CI, 1.05 to 10.81) of PI than that in the highest quartile (fourth quartile) of PI. PI (per 1% decrease) was associated with the development of cardiovascular death (HR, 1.38; 95% CI, 1.15 to 1.64). PI could be a novel indicator of cardiovascular death in patients with type 2 diabetes and established CVD.


H. Okada: None. Y. Okada: None. M. Fukui: None.

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