447-P: Bone Mineral Density Is Associated with Subclinical Atherosclerotic Cardiovascular Disease in Elderly Men with Type 2 Diabetes

The incidence of osteoporosis is controversial in type 2 diabetes(T2DM). There have been few studies to explore the influencing factors of bone mineral density (BMD) in old diabetic men. This study aimed to investigate the association of BMD with subclinical atherosclerotic cardiovascular disease in diabetic men. 295 diabetic men over 55 years old were enrolled divided into two groups: subclinical PAD and non-subclinical PAD group with age-, BMI-, and duration of diabetes- matched. The subclinical PAD was defined by ankle brachial index (ABI)≤0.9. BMD (at right hip, femoral neck and lumbar spine1-4 (L1-L4) by dual-energy X-ray absorptiometry), bone metabolic markers, ABI and routine anthropometric parameters were measured. Results showed that the incidence of osteoporosis had no difference(37.6% vs. 36.4 %,P=0.865). BMD at right hip were significantly lower in subclinical PAD group than non-subclinical PAD group (0.83±0.27g/cm² vs. 0.92±0.16g/cm², P=0.004). The T-score and Z-score at right hip, and T-score at femoral neck were significantly lower(-1.10±0.88vs. -0.69±0.97, P=0.005; -0.39±0.82 vs. -0.07±0.96, P=0.03;-1.36±0.92 vs. -0.99±1.04, P=0.02). BMD, T-score and Z-score at right hip were significantly associated with ABI(r=0.165,P=0.004; r=0.174,P=0.003, r=0.133,P=0.022).

In conclusion, BMD was associated with subclinical PAD in elderly men with type 2 diabetes. It suggests that vascular health, even in its early stages, is linked to bone health in elderly men with type 2 diabetes.