Objective: To study the association of triglycerides(TG), uric acid and incidence of type 2 diabetes mellitus(T2DM), evaluate whether there would be an additive interaction between two factors.
Methods: Based on the follow-up population of Jinchang cohort, an ongoing occupational-based prospective cohort study of 48,001 participants at baseline, the nested-case control study was used to explore the relationship of TG, uric acid and incidence of T2DM, and calculate the odds ratio(OR) and 95% confidence intervals(CI). The interaction additive model was used to evaluate whether there would be an additive interaction between two factors.
Results: Among 18,195 participants with normal fasting plasma glucose(FPG) at baseline, there were 267 incident diabetes cases during a median of 2.2 years of follow-up. With the increase of serum TG and uric acid, the cumulative incidences of diabetes in people with normal FPG at baseline were all rising (P for trend<0.05). After multivariable adjustments, the risk factors of diabetes were overweight/obesity(OR=2.30, 95%CI:1.72-3.08), hypertension(OR=2.42, 95%CI:1.78-3.29),hypertriglyceridemia(OR=1.49,95%CI:1.11-2.00), hyperuricemia(OR=2.32,95%CI:1.62-3.30), hypo high density lipoprotein cholesterolemia(OR=2.35, 95%CI:1.60-3.46). There was a positive additive interaction between hypertriglyceridemia and hyperuricemia on the development of diabetes from normal FPG. When they were co-existing, the risk of diabetes(OR, 95%CI) in the total, male and female population were 7.13 (4.70-10.83), 8.42 (5.13-13.83) and 7.09 (2.94-17.14),respectively.
Conclusion: Increased triglycerides and uric acid were strong risk factors of diabetes. Furthermore, there was a positive additive interaction between hypertriglyceridemia and hyperuricemia on the development of diabetes from normal fasting plasma glucose.
W. Huang: None. J. Yang: None. N. Liu: None. P. Huang: None. R. Zhang: None. R. Wang: None. Z. Bai: None. N. Cheng: None. M. Wang: None. S. Zheng: None. Y. Bai: None.
National Institutes of Health (1R01ES02908201A1); Lanzhou University (2018LDBRZD008)