Objective: There are few studies on the characteristics of 24-hour urinary electrolyte excretion in patients with type 2 diabetes mellitus (T2DM),and it is unclear whether the level of 24-hour urinary electrolyte excretion is related to poor renal prognosis.This study aimed to explore associations between 24-hour urinary electrolyte excretion and renal function in T2DM patients.

Methods: A total of 479 patients with T2DM in our hospital from 2018 to 2019 were enrolled. According to the estimated glomerular filtration rate (eGFR), patients were divided into normal group(eGFR≥90 mL/min/1.73m`2,n=317)and abnormal group(eGFR<90 mL/min/1.73m`2,n=162). The correlation between 24-hour urinary electrolyte excretion and eGFR in T2DM patients was analyzed. In addition, the 24-hour urine electrolyte excretion was compared with gender, diabetic duration, and HbA1c.

Results: The levels of 24-hour urinary potassium, sodium and chlorine excretion in abnormal group were higher than normal group, the levels of calcium and phosphorus excretion were lower. Therein, levels of sodium(P=0.037) and calcium (P<0.001) had significant difference. The levels of 24-hour urinary potassium, sodium, chloride, calcium and phosphorus excretion in the male group were higher than female group, among which potassium (P<0.001), sodium (P=0.001), chloride (P=0.002), and phosphorus (P<0.001) were statistically significant. In addition, duration of disease and HbAlc was not related to 24-hour Urinary Electrolyte Excretion.

Conclusion:There is a certain correlation between 24-hour urinary electrolyte excretion in T2DM and renal function. With the increase of 24-hour urinary sodium excretion and decrease of urinary calcium excretion, eGFR decreased, which was related to gender. Therefore, in patients with T2DM of the same gender, 24-hour urinary sodium and calcium excretion may be useful metabolic parameters for predicting poor renal prognosis, which needs further study.


Y. Wang: None. N. Li: None. L. Bu: None. H. Sun: None. B. Zhu: None. H. Li: None. S. Qu: None.


National Key Research and Development Program of China (2018YFC1314100); National Natural Science Foundation of China (81970677)

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