High-carbohydrate meals acutely impair endothelial function, whereas exercise, particularly high-intensity intermittent exercise (HIIE), plays a beneficial role. Data about the interaction of exercise and dietary intake on endothelial function are scarce. We, therefore, evaluated flow-mediated dilation (FMD) of the brachial artery (BA) as a standard measure of endothelial function after glucose drink ingestion immediately before or after HIIE. Healthy young volunteers (n = 11) participated in three protocols in random order. At 30 min before (preprandial Ex) or 15 min after (postprandial Ex) 500 mL glucose (75 g) drink ingestion, participants performed HIIE (28-min leg cycling). In control protocol (Con), participants ingested the same drink without exercise. FMD and blood flow profiles [ante- and retrograde shear rates (SRs)] were evaluated by ultrasound before and 60 and 120 min after glucose ingestion. Blood glucose (BG) and plasma insulin (PI) concentrations were measured. At 60 min after ingestion, postprandial Ex showed significantly higher %FMD (see Figure) and antegrade SR and lower BG and PI compared with Con and preprandial Ex.

In conclusion, postprandial HIIE effectively suppresses subsequent endothelial dysfunction via postprandial hyperglycemia suppression and antegrade shear stress elevation in the BA.


Y. Fukuba: None. H. Kashima: None. K. Miura: None. M.Y. Endo: None.


Japan Society for the Promotion of Science (17K01616); Uehara Memorial Life Science Foundation

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