The aims of this study were to investigate whether the stiffness of large elastic artery such as aorta and the muscular artery such as brachial artery improves through lifestyle modifications in type 2 diabetes. Total 82 overweight women with type 2 diabetes (age 55.0±7.6 years) were randomly assigned to control (C), diet (D), aerobic exercise (AE) and resistance exercise (RE) and completed the weight loss program for 12 weeks. We assessed BMI, augmentation index (AI) of aorta and also the flow-mediated dilation (FMD), the right brachial artery blood flow responses to an endothelium-independent vasodilator(ED), acetylcholine,, and an endothelium-dependent vasodilator(EID), isosorbide dinitrate, adiponectin/leptin ratio(ALR), free fatty acid(FFA), hsCRP, and insulin sensitivity (KITT) at baseline, and 12 week. There was no change in AI despite significant decreases in BMI in all intervention groups. FMD increased only in D and AE, but ED decreased in all 3 groups. EID increased only in D. The vascular function to sheer stress improved in muscular artery, not in large elastic artery with lifestyle changes. The response to isosorbide dinitrate was not consistent with FMD.
K. Han: None. B. Yang: None. K. Min: None.