Traditional metabolic heat conformation (MHC) method can be used for non-invasive blood glucose measurements when the body is in thermal equilibrium state. But in non-thermal equilibrium state, such as after meals, the traditional method may result in a poor accuracy. We propose a new method by extending the MHC principle to cover non-equilibrium state and develop a new measurement standard and calculation algorithm. The blood glucose measurement for the new algorithm is the sum of the blood glucose in equilibrium state and the blood glucose increase in non-equilibrium state. Results from clinical trials using this new method show significant improvement in accuracy of blood glucose measurements. Compared with the traditional MHC method, measurements using the new method results in improvement in correlation coefficients with intravenous blood-draw glucose concentration from 0.71 to 0.93 (for fasting measurements), from 0.61 to 0.93 (for measurements of 2 hours after a meal) and from 0.63 to 0.89 (for measurements of 3.5 hours after a meal). Applying Parkes Error Standard analysis, in the traditional MHC method, Range A (relative error does not exceed ±20%) accounts only for 54.3%, Range B (relative error does not exceed ±50%) accounts for 39.6%. In the new method, Range A accounts for 81.1%, and Range B accounts for 16.2%.


H.S. Tan: None. Z. He: None.

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