Objective: The relationship of serum 25-hydroxyvitamin D (25(OH)D) with type 2 diabetes(T2DM) is controversial and the correlation between 25 (OH) D and lipid metabolism is not clear. Therefore, our study intends to unveil the effect of 25(OH)D on blood lipid profile in T2DM.

Methods: A total of 587 patients with T2DM and 532 healthy people in our hospital from 2017 to 2018 were enrolled. The level of 25(OH)D between T2DM group and non-DM group was compared. Patients with T2DM were divided into a low 25(OH)D group(LVD group, <47.7nmol/L,n=425) and normal 25(OH)D group(NVD group, ≥47.7nmol/L,n=162). Furthermore, we analyzed the association between the level of 25(OH)D with patients’ BMI, age, TC, TG, HDL-C, and LDL-C. According to the diabetic duration, HbA1c, and vascular lesion, the relationship between 25 (OH) D and the severity of diabetes was compared.

Results: The level of 25(OH)D in the T2DM group was significantly lower than the non-DM group (39.99±15.25 vs.50.00±11.53, P<0.001). Level of TC (4.49(3.69∼5.34) vs. 4.09(3.45∼4.85), P<0.001), TG (1.46(1∼2.29) vs. 1.19(0.87∼1.73), P<0.001), LDL-C(2.75(2.07∼3.39) vs.2.44(1.96∼3.07), P=0.014) in the low 25(OH)D group were higher than normal group, and they all had significant difference. The level of HDL-C is lower (1.08(0.9∼1.33) vs. 1.13(0.97∼1.32), P=0.206), but there was no significant difference. In addition, gender, age, and BMI were found not related to 25(OH)D. Regression analysis showed that with the increase of diabetic duration and HbA1c, the level of 25(OH)D decreased, then the incidence of the vascular lesion was increased, but the difference was not statistically significant.

Conclusion: The 25(OH)D in patients with T2DM is lower than healthy people. Meanwhile, the atherosclerosis factors like TC, TG, and LDL-C are increased, but there is no definite correlation with HDL-C. Hence, we conclude that in patients with T2DM, supplementation of 25(OH) D may suppress the atherogenesis by regulating lipid metabolism, which needs further study.


N. Li: None. Y. Wang: None. B. Zhu: None. H. Sun: None. P. Yang: None. L. Zhang: None. H. Li: None. S. Qu: None.


National Natural Science Foundation of China (81900781, 81970677); National Key Research and Development Program of China (2018YFC1314100)

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