Aims: Standardized continuous glucose monitoring (CGM) metrics for clinical care were announced in 2019. There have been no reports, however, on the relationship between standardized CGM metrics and oxidative stress. We therefore decided to investigate the relationships between standardized CGM metrics, classical glycemic variability, and oxidative stress.

Methods: This study was a cross-sectional analysis of 117 patients with type 2 diabetes mellitus (T2DM). Oxidative stress was estimated using the diacron-reactive oxygen metabolites (d-ROMs) test. The following parameters were used as CGM metrics: mean glucose level (MGL), percentage coefficient of variation for glucose (%CV), time above range (TAR), time in range (TIR), time below range (TBR), standard deviation (SD), and mean amplitude of glycemic excursions (MAGE), a classic index.

Results: A total of 117 patients (mean age of 64.1 ± 12.6 years, mean disease duration of 13.1 ± 11.5 years, and HbA1c of 8.3 ± 1.5%) who met the study inclusion criteria were finally analyzed. The univariate analysis showed that age, triglyceride, HbA1c, MGL, %CV, SD, MAGE, and TAR were significantly correlated with d-ROMs. Further, a stepwise multiple regression analysis identified SD, MAGE, and sex as independent contributors to d-ROMs.

Conclusions: Oxidative stress was associated with the SD and MAGE, two parameters affected by the mean glucose level, as CGM metrics in patients with T2DM.


Y. Kohata: None. M. Ohara: None. T. Fujikawa: None. H. Nagaike: None. H. Kushima: None. M. Hiromura: None. Y. Mori: Research Support; Self; Taisho Pharmaceutical Co., Ltd. T. Fukui: None. T. Hirano: None. S. Yamagishi: None.

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